Close follow-up with healthcare providers and creation of a pain management plan is an effective way to manage chronic pain. This plan may include limiting opioid medicines to the lowest effective dose for a limited period of time. The plan may also include non-medicine treatments such as relaxation techniques, massage therapy, or transcutaneous electrical stimulation (TENS). OxyContin is a brand-name version of the extended-release form of oxycodone. OxyContin and immediate-release oxycodone belong to a drug class called opioids. A class of drugs is a group of medications that work in a similar way and are often used to treat similar conditions.
Patient Counseling Information
While opioids don’t work in the same way, they do have effects that slow down the central nervous system. Although the exact mechanism of how oxycodone works is not entirely understood, it attaches to receptors in the brain that are specialized for neurotransmitters like endorphins and enkephalins. Technically, oxycodone and other similar drugs are classified as endogenous opiate agonists, indicating that these drugs act on specific receptor sites in the brain that are involved in the subjective experience of pain. Noroxycodone, which is considered an inactive metabolite, is less potent than oxycodone 78.
The safety and efficacy of OXYCONTIN have been established in pediatric patients ages 11 to 16 years. Use of OXYCONTIN is supported by evidence from adequate and well-controlled trials with OXYCONTIN in adults as well oxycodone and alcohol: is there a safe way to mix them delphi as an open-label study in pediatric patients ages 6 to 16 years. However, there were insufficient numbers of patients less than 11 years of age enrolled in this study to establish the safety of the product in this age group. Inform patients that anaphylaxis has been reported with ingredients contained in OXYCONTIN.
Choosing an OTC Pain Reliever: What to Consider
Depending on your individual situation, your treatment plan could be either outpatient or inpatient. You stay at your home during outpatient treatment while you stay at a rehabilitation facility during inpatient treatment. Your healthcare provider will work with you to discuss your options, the pros and cons of each, and how much they may cost. There are several treatments available for oxycodone or alcohol addiction.
It is not known whether these effects on fertility are reversible see Use In Specific Populations. Inform patients that OXYCONTIN may cause orthostatic hypotension and syncope. Advise patients and caregivers that when medicines are no longer needed, they should be disposed of promptly. Expired, unwanted, or unused OXYCONTIN should be disposed of by flushing the unused medication down the toilet if a drug take-back option is not readily available. Inform patients that they can visit /drugdisposal for a complete list of medicines recommended for disposal by flushing, as well as additional information on disposal of unused medicines.
International Patients
- Oxycodone is commonly prescribed to individuals recovering from surgery or experiencing chronic pain due to medical conditions such as cancer or severe injuries.
- As a guideline for pediatric patients 11 years and older, the total daily oxycodone dosage usually can be increased by 25% of the current total daily dosage.
- Some individuals may also experience more severe side effects, such as respiratory depression or allergic reactions, which require immediate medical attention.
- Monitor infants exposed to OXYCONTIN through breast milk for excess sedation and respiratory depression.
- The process of quitting oxycodone and alcohol can be dangerous and may involve serious withdrawal symptoms.
When this valve spasms, it may feel like getting a tight muscle cramp, causing pain and blocking the flow of these juices, which can lead to discomfort and digestive problems. Stop taking oxycodone/acetaminophen and get emergency help if you have new or worse stomach pain or pain in the upper right side of your stomach-area that travels to your back or shoulder, with or without nausea and vomiting. While less common, the most serious side effects of oxycodone/acetaminophen are described below, along with what to do if they happen.
Treatment Options for Oxycodone and Alcohol Abuse
Some noroxycodone is also produced as a result of first-pass metabolism by CYP3A4/5 in the intestine 13, 35. Noroxycodone is considered to be inactive; when noroxycodone formation is blocked by the inhibition of CYP3A4/5, the analgesic effect of oxycodone is increased 42, 43. Oxycodone and Percocet are both very powerful prescription opioid pain medications with a high misuse potential, but they’re not exactly the same. They start to relieve pain within 2 to 4 hours of taking them, and steadily release the oxycodone for about 12 hours. Percocet is a brand name for the combination of oxycodone and acetaminophen (Tylenol). Cutting, breaking, chewing, crushing or dissolving OXYCONTIN impairs the controlled-release delivery mechanism and results in the rapid release and absorption of a potentially fatal dose of oxycodone.
- These effects could be more pronounced with concomitant use of OXYCONTIN and CYP2D6 and CYP3A4 inhibitors, particularly when an inhibitor is added after a stable dose of OXYCONTIN is achieved see WARNINGS AND PRECAUTIONS.
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- For some, it means counting on their loved ones to help them get out of the danger zone while for others, the only way out is through professional addiction treatment programs and support groups.
Using an opiate with alcohol would formally qualify as misuse of the drug due to the instructions on the label prohibiting the use of it in conjunction with alcohol. Therefore, some people may transition on to more prolonged or significant forms of substance abuse. Individuals often can’t conceptualize the ramifications of their behavior when they are under the influence of these drugs. Combining them can lead to an increased risk for self-harm or harm to others due to the behaviors individuals may engage in under the influence.
Pinpoint pupils are a sign of opioid overdose but are not pathognomonic (e.g., pontine lesions of hemorrhagic or ischemic origin may produce similar findings). Marked mydriasis rather than miosis may be seen with hypoxia in overdose situations see OVERDOSE. In case of overdose, priorities are the reestablishment of a patent and protected airway and institution of assisted or controlled ventilation, if needed. Employ other supportive measures (including oxygen, vasopressors) in the management of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias will require advanced life support measures. The most frequent adverse events observed in pediatric patients were vomiting, nausea, headache, pyrexia, and constipation see DOSAGE AND ADMINISTRATION, ADVERSE REACTIONS, CLINICAL PHARMACOLOGY and Clinical Studies.
Increased Chance of Overdose
In this study, OXYCONTIN 20 mg, but not 10 mg, was statistically significant in pain reduction compared with placebo. OXYCONTIN in healthy subjects in pharmacokinetic studies, steady-state levels were achieved within hours. Oxycodone is extensively metabolized and eliminated primarily in the urine as both conjugated and unconjugated metabolites. The apparent elimination half-life (t½) of oxycodone following the administration of OXYCONTIN was 4.5 hours compared to 3.2 hours for immediate-release oxycodone. Use of opioids for an extended period of time may cause reduced fertility in females and males of reproductive potential. It is not known whether these effects on fertility are reversible see ADVERSE REACTIONS, CLINICAL PHARMACOLOGY and Nonclinical Toxicology.
Oxycodone and Percocet drug interactions
In addition, discontinuation of a concomitantly used cytochrome P450 3A4 inducer may result in an increase in oxycodone plasma concentration. Monitor patients receiving OXYCONTIN and any CYP3A4 inhibitor or inducer see WARNINGS AND PRECAUTIONS , DRUG INTERACTIONS , CLINICAL PHARMACOLOGY. Serious, life-threatening, or fatal respiratory depression may occur with the use of OXYCONTIN.
Consider prescribing naloxone for the emergency treatment of opioid overdose see DOSAGE AND ADMINISTRATION and Life-Threatening Respiratory Depression. Individually titrate OXYCONTIN to a dosage that provides adequate analgesia and minimizes adverse reactions. Frequent communication is important among the prescriber, other members of the healthcare team, the patient, and the caregiver/family during periods of changing analgesic requirements, including initial titration.